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教授

高峰

  • 职称:教授
  • 出生年月:
  • 专业:生物物理学/生物信息学
  • Email:fgao@tju.edu.cn
  • 课题组网址:https://tubic.org/
  • 办公室:天津大学北洋园校区32号楼523房间
? 研究方向

研究方向1:生物信息学

研究方向2:微生物基因组学

研究方向3:生物大数据与人工智能

学习与工作简历

学习经历

1997年9月~2001年7月 天津大学理学院应用物理学专业 本科

2001年9月~2004年3月 天津大学理学院生物物理学专业 硕士 导师:张春霆 院士

2004年3月~2007年3月 天津大学理学院生物物理学专业 博士 导师:张春霆 院士

工作经历

2007年4月~2009年6月 天津大学理学院应用物理系 讲师

2009年7月~2015年6月 天津大学理学院应用物理系 副教授

2015年7月~至今 天津大学理学院应用物理系 教授

2014年~至今 天津大学理学院应用物理系 博士生导师

指导研究生情况

目前指导博士生3名,硕士生6名。
    2023级博士研究生 赵晓宇 (获批天津大学研究生文理拔尖创新奖励计划项目(重点项目),中期考核优秀)
    2024级博士研究生 孙博
    2025级博士研究生 李宇杰
    2023级研究生 曹淑媛(中国农业大学保研)耿钰清(河南工业大学保研,荣获研究生国家奖学金)
    2024级研究生 由芷菘(天大保研)冯鑫
    2025级研究生 张泽同(天大保研)孟繁悦(天大保研)
      已毕业研究生:
    2011级研究生罗昊(天大保研),2016年博士毕业,天津大学工作(副教授)。
    2012级研究生彭冲(天大保研,硕博连读),2018年博士毕业,天津科技大学工作(讲师)。
    2013级研究生张曦,2016年硕士毕业,加拿大西安大略大学(Western University)理学院生物系读博,获全额奖学金资助。
    2014级研究生张歌(天大保研),2017年硕士毕业,天津大学工作。
    2016级博士研究生杨志凯,2019年博士提前半年毕业,广州医科大学工作(南山学者副教授)。
    2016级研究生全春兰(河北大学保研),2019年硕士毕业,天津嘉立荷牧业集团有限公司工作。
    2017级博士研究生王丹(读博期间曾赴 Université Nice Sophia Antipolis 法国尼斯大学  Gianni LITI教授研究组交流半年),2020年博士毕业,天津医科大学工作(讲师)。
    2017级研究生乌浩,2020年硕士毕业(毕业论文荣获2022年度天津市优秀硕士学位论文,天津大学优秀毕业生),北京大学读博。
    2018级研究生刘淘(延边大学保研),2021年硕士毕业,天津南开日新国际学校(现在北京师范大学天津附属中学工作),教师。
    2019级博士研究生闫芳芳,2022年博士毕业(毕业论文荣获天津大学2022年优秀博士学位论文),山东农业大学(副教授,入选山东省青年科技人才托举工程)。
    2019级研究生张怡(河北大学保研),2022年硕士毕业,北京诺禾致源科技股份有限公司工作。
    2019级研究生杨彤,2022年硕士毕业(毕业论文荣获天津大学2023年优秀硕士学位论文),天津诺禾致源科技有限公司工作。
    2020级博士研究生董美敬,2023年博士毕业(毕业论文荣获天津大学2023年优秀博士学位论文),天津医科大学工作(讲师)。
    2020级研究生钟鸿昇(天津大学保研),2023年硕士毕业,天津大学微电子学院读博。
    2021级博士研究生赖飞燎,2024年博士毕业(毕业论文荣获天津大学2024年优秀博士学位论文),福建农林大学工作(讲师)。
    2021级研究生梁雅婷(东北大学保研),2024年硕士毕业,中国科学院近代物理研究所工作。
    2022级博士研究生殷振宁,2025年博士毕业,天津医科大学(博后)。

天津大学生物信息中心(主页 http://tubic.org)欢迎有 物理学、计算机、分子生物学或数学背景的同学前来报考。

主要研究成果

高峰,男,46岁,天津大学英才教授、博导,系统生物工程教育部重点实验室副主任,天津大学生物信息中心主任,合成生物技术全国重点实验室PI,师从生物信息学家张春霆院士攻读硕士、博士学位。主要从事微生物基因组生物信息学与合成生物学研究,已在Science等刊物发表SCI论文100篇(ESI高被引论文8篇,热点论文2篇),获Google Scholar 5400 余次引用,h 指数35(SCI引用4200余次),并被140余本国际英文书籍所引用。其中,第一(通讯)作者SCI论文76篇(影响因子3以上刊物论文69篇),包括Nucleic Acids Research(7)、Briefings in Bioinformatics(11)和Bioinformatics(7)系列25篇;唯一第一(通讯)作者论文57篇(包括Nucleic Acids Research 5篇, PNAS, iMeta, JACS Au, Genomics Proteomics & Bioinformatics, Briefings in Bioinformatics 8篇, Bioinformatics 7篇,Journal of Infection 3篇);双通讯(17篇)和双共一(2篇)SCI论文19篇(包括Nucleic Acids Research 2篇, Briefings in Bioinformatics 3篇, Genomics Proteomics & Bioinformatics, BMC Biology)。作为第一(通讯)作者先后为Springer出版社的Methods in Molecular Biology系列丛书撰写了两个章节,作为客座主编/编辑出版专刊书籍四本。第一(通讯)作者论文SCI引用1900余次(有10篇SCI引用超过50次,4篇超过100次),获Nature、Science、Cell等期刊论文引用并佐证,相关成果得到中央电视台、《科技日报》、《人民日报》等国家级媒体报道,以及90余本国际英文专著、教材、辞典、百科全书等引用。从2007年参加工作以来一直从事基因组复制起始点的相关研究,系统建立和发展了细菌(含质粒)、古菌、真核基因组复制起始点预测软件和数据库。其中,原核基因组复制起始点系列预测软件Ori-Finder(单篇最高SCI引用230余次,曾入选ESI高被引论文)以及数据库DoriC(单篇最高SCI引用100余次)累计SCI引用600余次。Ori-Finder已经成功应用于Cell (Hackl et al., Cell, 2023)、Nature (Graf et al., Nature, 2021)、Nature Microbiology(Needham et al., Nature Microbiology, 2022)等刊物发表新测序基因组的复制起始点预测。美国科学院院士、美国工程院院士、哈佛医学院遗传学系教授George M. Church 课题组在Nature Reviews Methods Primers的综述论文中,推荐Ori-Finder作为复制?。╮eplichore)识别的工具 (Wannier et al., Nature Reviews Methods Primers, 2021)。以色列威茨曼研究所的Eran Segal教授课题组(Korem et al., Science, 2015) 发现,基于宏基因组测序分析的结果与DoriC数据库中关于上百株肠道微生物复制起始点的预测结果具有高度一致性 (R2 = 0.98, P < 10?30)。英国纽卡斯尔大学的Heath Murray教授课题组在模式生物枯草芽孢杆菌的研究中发现,位于染色体复制起始点解旋区的重复性三核苷酸基序(DnaA-trios)是复制起始蛋白DnaA打开DNA双螺旋所必需的元件,普遍存在于DoriC数据库代表性物种预测复制起始点内(Richardson et al., Nature, 2016)。先后主持基因组复制起始点相关的国家自然科学基金项目(5项)、国家重点研发计划课题(课题经费1091万)。

Web of Science: https://www.webofscience.com/wos/author/record/1506509
ORCID: http://orcid.org/0000-0002-9563-3841
Google scholar: http://scholar.google.com/citations?user=_jqaatIAAAAJ&hl=en
ResearcherID: http://www.researcherid.com/rid/C-9913-2009
Publication as Corresponding Author:
1. Huang, H, Yang, Z-L, Wu, X-M, Wang, Y, Liu, Y-J, Luo, H, Lv, X, Gan, Y-R, Song, S-D, Gao, F*: Complete genome sequence of Acinetobacter baumannii MDR-TJ and insights into its mechanism of antibiotic resistance. Journal of Antimicrobial Chemotherapy 2012, 67(12):2825-2832 (被Clinical Infectious Diseases、Gut Microbes等杂志SCI引用63次).
2. Gao, F*, Luo, H, Zhang, C-T*: DoriC 5.0: an updated database of oriC regions in both bacterial and archaeal genomes. Nucleic Acids Research 2013, 41(D1):D90-D93 (被Cell,Science,Nature,Nature Biotechnology, Nature methods等杂志SCI引用107次).
3. Gao, F*: Recent Advances in the identification of replication origins based on the Z-curve method. Current Genomics 2014, 15(2):104-112 (被The ISME Journal等杂志SCI引用17次).
4. Huang, H, Dong, Y, Yang, ZL, Luo, H, Zhang, X, Gao, F*: Complete sequence of pABTJ2, a plasmid from Acinetobacter baumannii MDR-TJ, carrying many phage-like elements. Genomics, Proteomics & Bioinformatics 2014, 12(4):172-177 (被Genome Biology等杂志SCI引用20次).
5. Luo, H, Zhang, C-T*, Gao, F*: Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes. Frontiers in Microbiology 2014, 5:482 (被Microbiome、Nature Communications等杂志SCI引用71次).
6. Peng, C, Gao, F*: Protein localization analysis of essential genes in prokaryotes. Scientific Reports 2014, 4:6001 (被PNAS、Briefings in Bioinformatics等杂志SCI引用48次).
7. Gao, F*: Bacteria may have multiple replication origins. Frontiers in Microbiology 2015, 6:324 (被Annual Review of Microbiology, Nature Communications等杂志SCI引用17次).
8. Huang, H, Song, C-C, Yang, Z-L, Dong, Y, Hu, Y-Z, Gao, F*: Identification of the replication origins from Cyanothece ATCC 51142 and their interactions with the DnaA protein: from in silico to in vitro studies. Frontiers in Microbiology 2015, 6:1370.
9. Jia, N, Du, J, Ding, M-Z, Gao, F*, Yuan, Y-J*: Genome sequence of Bacillus endophyticus and analysis of its companion mechanism in the Ketogulonigenium vulgare-Bacillus strain consortium. PLoS ONE 2015, 10(8):e0135104 (被Biotechnology advances等杂志SCI引用19次).
10. Peng, C, Luo, H, Zhang, X, Gao, F*: Recent advances in the genome-wide study of DNA replication origins in yeast. Frontiers in Microbiology 2015, 6:117 (SCI引用19次).
11. Zhang, X, Peng, C, Zhang, G, Gao, F*: Comparative analysis of essential genes in prokaryotic genomic islands. Scientific Reports 2015, 5:12561 (SCI引用10次).
12. Gao, F*: Editorial: DNA replication origins in microbial genomes. Frontiers in Microbiology 2016, 6:1545 (SCI引用3次).
13. Jia, N, Ding, M-Z*, Du, J, Pan, C-H, Tian, G, Lang, J-D, Fang, J-H, Gao, F*, Yuan, Y-J: Insights into mutualism mechanism and versatile metabolism of Ketogulonicigenium vulgare Hbe602 based on comparative genomics and metabolomics studies. Scientific Reports 2016, 6:23068 (被Biotechnology advances等杂志SCI引用21次).
14. Jia, N, Ding, M-Z*, Gao, F*, Yuan, Y-J: Comparative genomics analysis of the companion mechanisms of Bacillus thuringiensis Bc601 and Bacillus endophyticus Hbe603 in bacterial consortium. Scientific Reports 2016, 6:28794 (SCI引用15次).
15. Jia, N, Ding, M-Z*, Du, Y-Z, Feng, S, Gao, F*, Yuan, Y-J: Complete genome sequence of the industrial bacterium Ketogulonicigenium vulgare SKV. Genome Announc 2016, 4(6):e01426-16 (SCI引用5次).
16. Jia, N, Ding, M-Z*, Luo, H, Gao, F*, Yuan, Y-J: Complete genome sequencing and antibiotics biosynthesis analysis of Streptomyces lydicus 103. Scientific Reports 2017, 7:44786 (SCI引用15次).
17. Jia, N, Ding, M-Z*, Zou, Y, Gao, F*, Yuan, Y-J: Comparative genomics and metabolomics analyses of the adaptation mechanism in Ketogulonicigenium vulgare-Bacillus thuringiensis consortium. Scientific Reports 2017, 7:46759 (被Biotechnology Advances等杂志SCI引用13次).
18. Zhang, G, Gao, F*: Quantitative analysis of correlation between AT and GC biases among bacterial genomes. PLoS ONE 2017, 12(2):e0171408 (被Nucleic Acids Research等杂志SCI引用21次).
19. Peng, C, Lin, Y, Luo, H and Gao, F*: A comprehensive overview of online resources to identify and predict bacterial essential genes. Frontiers in Microbiology 2017, 8:2331 (被Briefings in Bioinformatics, Bioinformatics等杂志SCI引用37次).
20. Yang, Z-K, Gao, F*: The systematic analysis of ultraconserved genomic regions in the budding yeast. Bioinformatics 2018, 34(3):361-366.(SCI引用2次)
21. Yang, Z-K, Luo, H, Zhang, Y, Wang, B and Gao, F*: Recombinational DSBs-intersected genes converge on specific disease- and adaptability-related pathways. Bioinformatics 2018, 34(20):3421-3426.(新闻报道
22. Yang, Z-K, Luo, H, Zhang, Y,Wang, B and Gao, F*: Pan-genomic analysisprovides novel insights into the association of E. coli with human host and its minimal genome. Bioinformatics 2019, 35(12):1987-1991 (被Nature Reviews Microbiology等杂志SCI引用23次).
23. Luo, H, Quan, C-L, Peng, C and Gao, F*: Recent development of Ori-Finder system and DoriC database for microbial replication origins. Briefings in Bioinformatics 2019, 20(4):1114–1124(被Trends in Biochemical Sciences、EMBO Journal等杂志SCI引用35次).
24. Gao, F*: Recent developments of software and database in microbial genomics and functional genomics. Briefings in Bioinformatics 2019, 20(2): 732–734.(新闻报道)(SCI引用4次)
25. Luo, H, Gao, F*: DoriC 10.0: an updated database of replication origins in prokaryotic genomes including chromosomes and plasmids. Nucleic Acids Research 2019, 47(D1):D74-D77 (被Annual Review of Microbiology、Genome Research、PLoS genetics等杂志SCI引用62次)(荣获2020全国博士后人工智能发展与应用论坛优秀奖).
26. Quan, C-L, Gao, F*: Quantitative analysis and assessment of base composition asymmetry and geneorientation bias in bacterial genomes. FEBS Letters 2019, 593(9):918-925 (SCI引用2次).
27. Wang, D and Gao, F*: Comprehensive Analysis of Replication Origins in Saccharomyces cerevisiae Genomes. Frontiers in Microbiology 2019, 10:2122 (SCI引用9次).
28. Gao,F*,Leonard, AC*: Editorial: DNA Replication Origins in Microbial Genomes, Volume 2. Frontiers in Microbiology 2019, 10:2416.
29. Bai, L, Zhang, S, Deng, Y, Song, C, Kang, G, Dong, Y, Wang, Y, Gao, F* & Huang, H*: Comparative genomics analysis of Acinetobacter haemolyticus isolates from sputum samples of respiratory patients. Genomics 2020, 112(4):2784-2793 (SCI引用14次).
30. Yan, F, Gao, F*: A systematic strategy for the investigation of vaccines and drugs targeting bacteria. Computational and Structural Biotechnology Journal 2020, 18:1525-1538 (SCI引用15次).
31. Wu, H, Wang, D, Gao, F*: Toward a high-quality pan-genome landscape of Bacillus subtilis by removal of confounding strains. Briefings in Bioinformatics 2021, 22(2):1951-1971 (被Molecular Biology and Evolution、ISME Journal 、Nucleic Acids Research等杂志SCI引用36次).
32. Wang, D, Lai FL, Gao, F*: Ori-Finder 3: a web server for genome-wide prediction of replication origins in Saccharomyces cerevisiae. Briefings in Bioinformatics 2021, 22(3): bbaa182 (SCI引用9次).
33. Luo, H, Lin, Y, Liu, T, Lai, F-L, Zhang, C-T, Gao, F*& Zhang, R*: DEG 15, an update of the Database of Essential Genes that includes built-in analysis tools. Nucleic Acids Research 2021, 49(D1):D677–D686 (被Nature Biotechnology、Genome Medicine、Trends in Biotechnology、Nucleic Acids Research、Biotechnology Advances、JCI Insight 等杂志SCI引用165次,高被引论文).
34. Yan, F, Gao, F*: Comparison of the binding characteristics of SARS-CoV and SARS-CoV-2 RBDs to ACE2 at different temperatures by MD simulations. Briefings in Bioinformatics 2021, 22(2):1122-1136 (被Chemical Reviews、Chemical Society Reviews、Cell Chemical Biology、Research等杂志SCI引用30次). (人民日报)(科技日报)(人民网)(光明网)(联合早报)(鳳凰华人资讯网)(前瞻网
35. Liu, T, Luo, H*, Gao, F*: Position preference of essential genes in prokaryotic operons. PLoS ONE 2021, 16 (4):e0250380(被Nature Reviews Genetics杂志引用). (SCI引用3次)
36. Pelliciari, S, Dong, M-J, Gao, F* and Murray H*, Evidence for a chromosome origin unwinding system broadly conserved in bacteria, Nucleic Acids Research 2021, 49(13):7525–7536.(新闻报道) (SCI引用9次)
37. Yang, Z-K#*, Pan, L #, Zhang, Y#, Luo, H and Gao, F*, Data-driven identification of SARS-CoV-2 subpopulations using PhenoGraph and binary-coded genomic data, Briefings in Bioinformatics 2021, 22(6):bbab307 (#These authors contributed equally to this work) (荣获2021年度广州市医学会医学优秀学术论文二等奖)(新闻报道) (被Nature Communications、MedComm等杂志SCI杂志引用7次)
38. Yan, F, Gao, F*: An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2. Computational and Structural Biotechnology Journal 2021, 19:4868-4883 (SCI引用41次,热点文章).
39. Yan, F, Gao, F*:  EK1 with dual Q1004E/N1006I mutation: a promising fusion inhibitor for the HR1 domain of SARS-CoV-2, Journal of Infection 2022, 84(4):588-590. (被Signal Transduction and Targeted Therapy等杂志SCI引用5次)
40. Lai, F-L, Gao, F*:  GC-Profile 2.0: an extended web server for the prediction and visualization of CpG islands, Bioinformatics 2022, 38 (6):1738-1740. (SCI引用10次)
41. Li, P, Zhang, J, Deng, Z, Gao, F*, Ou, H-Y*:  Identification and characterization of a central replication origin of the mega-plasmid pSCATT of Streptomyces cattleya, Microbiological Research 2022, 257:126975.
42. Yang, T, Gao, F*: High-quality pan-genome of E. coli generated by excluding confounding and highly similar strains reveals an association between unique gene clusters and genomic islands, Briefings in Bioinformatics 2022, 23(4): bbac283. (被PNAS等杂志SCI引用11次)
43. Gao, F*, Huang, K*, Xing, Y*: Artificial Intelligence in Omics, Genomics, Proteomics & Bioinformatics 2022, 20(5):811–813. (被GUT、Biomarker Research等杂志SCI引用25次)
44. Dong, M-J#, Luo, H#, Gao, F*: Ori-Finder 2022: A Comprehensive Web Server for Prediction and Analysis of Bacterial Replication Origins, Genomics, Proteomics & Bioinformatics 2022, 20(6):1207-1213. (杂志公众号报道) (被Cell Host & Microbe、Current Biology等杂志SCI引用39次)
45. Dong, M-J#, Luo, H#, Gao, F*: DoriC 12.0: an updated database of replication origins in both complete and draft prokaryotic genomes, Nucleic Acids Research 2023, 51(6):D117–D120. (被Science, Nature Biotechnology, Nature Communications等杂志SCI引用20次)
46. Yan, F, Gao, F*:  RBD-ACE2 binding properties in five SARS-CoV-2 variants of concern with new perspectives in the design of pan-coronavirus peptide inhibitors, Journal of Infection 2023, 86(2):e51-e54. (SCI引用5次)
47. Lai, F-L, Gao, F*: Auto-Kla: A novel web server to discriminate lysine lactylation sites using automated machine learning, Briefings in Bioinformatics 2023, 24(2):bbad070.(公众号报道;被Trends in Endocrinology & Metabolism、Cancer Letters、Cell Death & Differentiation等杂志SCI引用44次)
48. Zhong, H-S, Dong, M-J, Gao, F*: G4Bank: A database of experimentally identified DNA G-quadruplex sequences, Interdisciplinary Sciences: Computational Life Sciences 2023, 15(3):515–523.(杂志公众号报道) (被Nucleic Acids Research、Genome Research、Journal of Big Data等杂志SCI引用8次)
49. Sun, B, Gao, F*: Investigation of escape mechanisms of SARS-CoV-2 Omicron sub-lineages and exploration of potential antibodies for XBB.1, Journal of Infection 2023, 87(4):354-357.
50. Perez-Rueda, E*, Gao,F*: Editorial: Insights in Evolutionary & Genomic Microbiology: 2022. Frontiers in Microbiology 2023, 14:1269933.
51. Lai, F-L, Gao, F*: LSA-ac4C: A hybrid neural network incorporating double-layer LSTM and self-attention mechanism for the prediction of N4-acetylcytidine sites in human mRNA, International Journal of Biological Macromolecules 2023, 253:126837. (SCI引用17次)
52. Liang, Y-T, Luo, H, Lin, Y, Gao, F*: Recent advances in the characterization of essential genes and development of a database of essential genes,  iMeta 2024, 3(1):e157.(杂志公众号报道) (被Drug Discovery Today等杂志SCI引用9次)
53. Yin, Z-N#, Lai, F-L#, Gao, F*: Unveiling human origins of replication using deep learning: accurate prediction and comprehensive analysis, Briefings in Bioinformatics 2024, 25(1):bbad432. (SCI引用4次)
54. Zhao, X, Gao, F*: Novel Omicron Variants Enhance Anchored Recognition of TMEM106B: A New Pathway for SARS-CoV-2 Cellular Invasion, Journal of Physical Chemistry Letters 2024, 15(3):671-680.(ACS美国化学会公众号报道)  (SCI引用4次)
55. Zeng, Y-H, Yin, Z-N, Luo, H*, Gao, F*: DeOri 10.0: An Updated Database of Experimentally Identified Eukaryotic Replication Origins, Genomics, Proteomics & Bioinformatics 2024, 22(5):qzae076.(杂志公众号报道
56.  Geng, Y-Q, Lai, F-L, Luo, H*, Gao, F*: Nmix: A hybrid deep learning model for precise prediction of 2'-O-methylation sites based on multi-feature fusion and ensemble learning, Briefings in Bioinformatics 2024, 25(6):bbae601. (SCI引用2次)
57.  Zhao, X, Gao, F*: Dynamic Mechanism of Norepinephrine Reuptake and Antidepressants Blockade Regulated by Membrane Potential, Journal of Chemical Theory and Computation 2025, 21 (5):2780-2797.
58. Li, Y, Gao, F*:  OriV-Finder: a comprehensive web server for bacterial plasmid replication origin analysis. Nucleic Acids Research, 2025, 53 (W1):W451–W456.
59. Cao, S#, Sun, B#, Gao, F*:  From Immune Evasion to Broad In Silico Binding: Computational Optimization of SARS-CoV-2 RBD-Targeting Nanobody. Frontiers in Immunology, 2025, 16:1637955.
60. Zhao, X, Gao, F*: Rocker-Switch Mechanism of Choline Transmembrane Transport in FLVCR2: Dynamic Latch Residues and Cooperative Regulation of Transmembrane Helices. JACS Au, 2025,  5(10):4936–4955.
61. Geng, Y-Q, Luo, H*, Gao, F*: AIPred: comprehensive prediction and analysis of non-histone acetylation via protein language model and interpretable machine learning, BMC Biology 2025, 23, 311.
Publication as First Author:
1. Gao, F, Ou, H-Y, Chen, L-L, Zheng, W-X, Zhang, C-T: Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes. FEBS Letters 2003, 553(3):451-456.(央视新闻报道)(科技日报)(教育部网站)(人民日报)(中国青年报)(科学时报)(被Chemical Reviews, JACS, ACS Catalysis, Journal of Virology (?9)? 等杂志SCI引用75次)
2. Gao, F, Zhang, C-T: Comparison of various algorithms for recognizing short coding sequences of human genes. Bioinformatics 2004, 20(5):673-681.(被Genome Research、eLife、MBE等杂志SCI引用53次,论文还多次被Duke University, MIT等国际知名高校的学位论文所引用)
3. Gao, F, Zhang, C-T: GC-Profile: a web-based tool for visualizing and analyzing the variation of GC content in genomic sequences. Nucleic Acids Research 2006, 34(W1):W686-W691(被Nature Reviews Microbiology、Nature Microbiology、Nature Communications、PLoS Biology等杂志SCI引用130次,论文还被Springer、Cambridge University Press等出版社的14本英文专著所引用).
4. Gao, F, Zhang, C-T: Isochore structures in the chicken genome. FEBS Journal 2006, 273(8):1637-1648 (SCI引用6次).
5. Gao, F, Zhang, C-T: DoriC: a database of oriC regions in bacterial genomes. Bioinformatics 2007, 23(14):1866-1867 (被Nature、Seminars in Cancer Biology、FEMS Microbiol Rev 等杂志SCI引用74次).
6. Gao, F, Zhang, C-T: Origins of replication in Cyanothece 51142. Proc Natl Acad Sci USA 2008, 105(52):E125 (被Current opinion in microbiology等杂志SCI引用15次).
7. Gao, F, Zhang, C-T: Prediction of replication time zones at single nucleotide resolution in the human genome. FEBS Letters 2008, 582(16):2441-2444.
8. Gao, F, Zhang, C-T: Origins of replication in Sorangium cellulosum and Microcystis aeruginosa. DNA Research 2008, 15(3):169-171 (SCI引用5次).
9. Gao, F, Zhang, C-T: Ori-Finder: A web-based system for finding oriCs in unannotated bacterial genomes. BMC Bioinformatics 2008, 9:79 (曾入选ESI高被引论文,被Cell、Nature、Nature Microbiology、Nature Reviews Methods Primers、Cell Host & Microbe、The ISME Journal、PNAS  等杂志SCI引用230次).
10. Gao, F, Wang, Y, Liu, Y-J, Wu, X-M, Lv, X, Gan, Y-R, Song, S-D, Huang, H: Genome Sequence of Acinetobacter baumannii MDR-TJ. Journal of Bacteriology 2011, 193(9):2365-2366 (被Nature Communications等杂志SCI引用23次).
11. Gao, F, Zhang, RR: Enzymes are enriched in bacterial essential genes. PLoS ONE 2011, 6(6):e21683 (SCI引用15次).
12. Gao, F#, Lin, Y#, Zhang, RR: RNA-DNA differences are rarer in proto-oncogenes than in tumor suppressor genes. Scientific Reports 2012, 2:245 (#These authors contributed equally to this work) (SCI引用2次).
13. Gao, F, Luo, H, Zhang, C-T: DeOri: a database of eukaryotic DNA replication origins. Bioinformatics 2012, 28(11):1551-1552 (被Molecular Cell、Cell Reports等杂志SCI引用31次).
14. Gao, F, Luo, H, Fu, Z, Zhang, C-T, Zhang, R: Exome sequencing identifies novel ApoB loss-of-function mutations causing hypobetalipoproteinemia in type 1 diabetes. Acta Diabetologica 2015, 52(3):531-537.
15. Wei, W#, Gao, F#, Du, M-Z, Hua, H-L, Wang, J, Guo, F-B: Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties. Briefings in Bioinformatics 2017, 18(3):357-366 (#These authors contributed equally to this work) (被FEMS Microbiology Reviews等杂志SCI引用38次).
Book:
1. Gao F, Luo H, Zhang CT, Zhang R*. (2015) Gene Essentiality Analysis Based on DEG 10, an Updated Database of Essential Genes. In: Lu L. (eds) Gene Essentiality. Methods in Molecular Biology, vol 1279. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2398-4_14 (被Nature Reviews Genetics、Nature Communications等杂志SCI引用33次).
2. Wu H, Yang ZK, Yang T, Wang D, Luo H, Gao F*. (2022) An Effective Preprocessing Method for High-Quality Pan-Genome Analysis of Bacillus subtilis and Escherichia coli. In: Zhang R. (eds) Essential Genes and Genomes. Methods in Molecular Biology, vol 2377. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1720-5_21
3. Gao, F ed.: DNA replication origins in microbial genomes. Lausanne: Frontiers Media 2016, doi: 10.3389/978-2-88919-779-8(新闻报道).
4. Gao, F., Leonard, A. C., eds. DNA Replication Origins in Microbial Genomes, Volume 2. Lausanne: Frontiers Media SA 2019. doi: 10.3389/978-2-88963-245-9.

荣誉和奖励

2017年2月,受美国国立人类基因组研究所主任Eric Green 和苏黎世联邦理工学院教授 Ruedi Aebersold 邀请加入 Faculty of 1000 (F1000) ,担任 Genomics & Genetics 领域专家,入选全球前2%顶尖科学家终身科学影响力榜单(Top 2% of Scientists on Stanford List;入选“终身科学影响力排行榜(1960-2022)”和“2022年度科学影响力排行榜”两个榜单)、教育部“新世纪优秀人才支持计划”、“天津市131创新型人才培养工程”和天津大学“北洋青年学者计划”。曾获中国青少年科技创新奖,全国优秀博士学位论文提名,天津市优秀硕士学位论文、天津大学优秀博士/硕士学位论文指导教师。担任iMeta (影响因子33.2),Genome Biology (影响因子9.4),Genomics Proteomics & Bioinformatics(影响因子7.9,入选中国科技期刊卓越行动计划英文领军期刊),Briefings in Bioinformatics (影响因子7.7),Interdisciplinary Sciences: Computational Life Sciences(影响因子3.9),Frontiers in Microbiology(影响因子4.5),BMC Microbiology(影响因子4.2),Scientific Reports (影响因子3.9),Microbiology Spectrum (影响因子3.8),PLoS ONE (影响因子2.6),《基因组学与应用生物学》(中文核心期刊)等国内外杂志编委/副主编(其中中科院分区一二区期刊8个)。作为特刊主编在Briefings in Bioinformatics 主持专刊 Recent developments of software and database in microbial genomics and functional genomics(包括美国科学院院士Eugene Koonin、美国艺术与科学院院士Steven Salzberg等通讯作者论文13篇,累计SCI引用8000余次),在Genomics Proteomics & Bioinformatics 主持专刊 Artificial Intelligence in Omics(包括来自哈佛大学、丹娜-法伯癌症研究所、康奈尔大学以及清华大学、北京大学等国内外知名大学、研究所的15篇论文,其中两篇论文曾入选Genomics Proteomics & Bioinformatics杂志创刊20周年Top下载20篇),在Frontiers in Microbiology 主持系列专刊 DNA Replication Origins in Microbial Genomes(包括 Volume I, Volume II 和 Volume III);作为客座编辑,在Frontiers in Microbiology 主持专刊Insights in Evolutionary and Genomic Microbiology: 2021(荣获Frontiers in Microbiology 杂志 Outstanding Research Topic 2022 证书)和Insights in Evolutionary & Genomic Microbiology: 2022。作为SCI杂志编委已累计处理稿件350余篇,荣获 Genomics, Proteomics & Bioinformatics (GPB) 杂志 Distinguished Editorial Board Member Award (2003-2023),Frontiers in Microbiology杂志Outstanding Editor Award(2021年度和2023年度),PLOS ONE杂志 Long Service Award,Scientific Reports杂志专访获Nature杂志公众号报道。先后担任国家重点研发计划评审专家(组长),国家高层次人才特殊支持计划(科技创新领军人才)等国家级高层次人才会评/函评专家,教育部科技奖励、学科评估以及国家自然科学基金通讯评审专家(评审各类国家基金上百项),中国科协科技人才奖项评审专家,高校计算机专业优秀教师奖励计划评审专家,北京市科学技术奖、自然科学基金(重点研究专题项目、交叉融合重点项目、联合基金项目等)评审专家、重庆市自然科学基金(面上项目)评审专家、广东省科技厅科技咨询专家库专家,天津市人民政府学位委员会学科评议组成员,天津市科技专家库专家,天津大学学位评定委员会分委员会委员,中国生物信息学学会(筹)理事、多组学与整合生物学专委会常委、筹备秘书处副秘书长,中国细胞生物学学会功能基因组信息学与系统生物学分会委员,中国计算机学会杰出会员、计算机应用专业委员会委员,中国医药生物技术协会生物医学信息技术分会委员,中国遗传学会生物大数据专业委员会委员,澳门生物信息学会理事,天津市人工智能学会理事,国家基因组科学数据中心合作伙伴等。受邀担任了Nature Communications, Genome Biology, Nucleic Acids Research, Genome Research, Cell Reports, iMeta, Genomics Proteomics & Bioinformatics, Briefings in Bioinformatics, Bioinformatics, BMC Biology, eLife, PLOS Computational Biology 以及 Science China-Life Sciences 等一百多个SCI 刊物的审稿人(详见 Web of Science),VinFuture Prize 全球科技奖提名专家,中文期刊《生物信息学》(2021)和《基因组学与应用生物学》(2023,2024)优秀审稿人。连续担任七届全国生物信息学与系统生物学学术大会学术委员会/程序委员会委员、“微生物组学分析方法与应用”分会(第九届)召集人,第七届GPB组学与生物信息学前沿研讨会(GFS2023) 组织委员会委员、“人工智能与组学数据应用”专题召集人,第八届国际生物信息学论坛(The 8th International Bioinformatics Workshop) 程序委员会委员,ISMB/ECCB生物信息学国际顶会以及IBW、CBC、NCCA等国内会议的审稿专家。

讲授主要课程

《大学物理》、《生物信息学》、《生物物理导论》、《生物信息学导论》(研究生)

主持科研项目

正在承担项目: 

1.主持国家自然科学基金(面上基金),项目名称为“人类复制起始点系统化特征提取及全基因组预测分析”(项目编号:32270692),资助经费54万元(直接经费),执行期限为2023.1-2026.12,负责人,在研。

已完成项目:

1.主持国家自然科学基金(科学部主任基金),项目名称为“真核生物全基因组范围复制起始点的预测”(项目编号:10747150),资助经费2万元,执行期限为2008.1-2008.12,负责人,已结题。

2.主持国家自然科学基金(青年基金),项目名称为“微生物基因组复制起始区的系统化识别及功能性分析”(项目编号:30800642),资助经费16万元,执行期限为2009.1-2011.12,负责人,已结题。

3.主持国家自然科学基金(面上基金),项目名称为“上千种细菌基因组复制起始区的规律提取及应用”(项目编号:31171238),资助经费60万元,执行期限为2012.1-2015.12,负责人,已结题。

4.主持教育部新世纪优秀人才支持计划项目(项目编号:NCET-12-0396),资助经费50 万元,执行期限为2013.1-2015.12,负责人,已结题。

5.主持国家自然科学基金(面上基金),项目名称为“酿酒酵母全基因组复制起始点的系统化分析及识别”(项目编号:31571358),资助经费57万元(直接经费),执行期限为2016.1-2019.12,负责人,已结题。

6.主持国家重点研发计划课题,课题名称为“大肠杆菌基因组的理性设计与化学合成 ”(课题编号: 2018YFA0903702),课题经费1091万,执行期限为2019 .7-2024.6,课题负责人,已结题。

7.参加国家自然基金(重大研究项目),项目名称为“人与其它高等真核生物全基因组中的Isochore结构研究” (项目编号:90408028),资助经费40万元,执行期限为2005.1-2007.12,主要参与人,已结题。

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